Protein Kinase Functions

Since the publication of "Protein Kinases" in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been advances in our understanding of the cellular functions of this diverse class of proteins.

This text is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the advances in kinase biology.

Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFb superfamily, and the involvement of protein kinases in response to DNA damage.

Throughout, emphasis is placed not on individual kinases, but on the functional aspects of the whole system and the relationship between processes and molecules.

It aims to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to their environments.