Regulation of Gene Expression

A guide through the cellular processes which govern gene expression, starting with transcription initiation and highlighting universal principles.

The essays provide insights into present work and concepts which are elucidating the mechanisms that lead to protein synthesis in the correct cell at the precise time and in response to appropriate signals.

Epigenetic mechanisms are described by which information about the regulatory state of a gene is transmitted to a cells descendants.

Aspects of gene regulation by extracellular and intracellular signalling pathways are discussed, as well as post-transcriptional control of gene expression.

Also illustrated in the book is the crucial importance in normal development and growth of the coupling of gene expression to cell cycle progression - where dysregulation can lead to cell death or innapropriate proliferation.