Hereditary Sensory and Autonomic Neuropathy

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Hereditary sensory and autonomic neuropathy (HSAN) or hereditary sensory neuropathy (HSN) is a condition used to describe any of the types of this disease which inhibit sensation.

They are less common than Charcot-Marie-Tooth disease.

Five different clinical entities have been described under hereditary sensory and autonomic neuropathies - all characterized by progressive loss of function that predominantly affects the peripheral sensory nerves.

Their incidence has been estimated to be about 1 in 25,000.Type 1 is transmitted as autosomal dominant trait and is characterized by a sensory deficit in the distal portion of the lower extremities, chronic perforating ulcerations of the feet and progressive destruction of underlying bones.

Sweating abnormalities occur but other autonomic features are not found in this type.

Symptoms appear in late childhood on early adolescence with trophic ulcers as pain sensation is affected more.