Target organ toxicityVolume 2

First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity.

Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively.

These general principles are then illustrated using specific examples of toxicity to different target organs and systems.

DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined.

Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.