Introduction to Statistical Methods for Clinical Trials

Clinical trials have taken a prominent role in the research and approval of new drugs.

To conduct rigorous clinical studies, present and future biostatisticians need a good background in the design and analysis of data gleaned from those studies.

This text provides a summary of statistical design, including cross-over designs, sample size estimation, sequential methods for interim analyses, survival analysis, and repeated measures.

The authors also discuss a number of topics not addressed in other books on the subject, including the use of surrogate variables, meta-analysis, and longitudinal designs.

Each chapter includes examples and exercises, and data sets are available for download from the Internet.