Preclinical Drug Discovery : Biochemical Methods in High Throughput Screening

This book provides theoretical, practical and troubleshooting guidelines on biochemical methods in high-throughput screening as part of the pre-clinical Drug Discovery process.

There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of "Hits" to "Leads" and "Candidates". The book will cover colorimetric, fluorescence resonance energy transfer, luminescence, scintillation proximity and enzyme-linked immunosorbent assays in detail, and contains comprehensive appendices providing detailed information on commercially available assays currently available. This text will provide an invaluable guide for biochemists and medicinal chemists working in the pharmaceutical industry and academia.