G Proteins

This book discusses the heterotrimeric GTB-binding proteins (G proteins) that couple a vast array of receptors for extracellular signals to diverse effectors such as enzymes of second messenger metabolism and ion channels.

The focus is on mammalian G proteins, but a chapter on G proteins in diverse invertebrates is included.

The role of abnormal G proteins in human diseases is examined, both in terms of those disorders in which specific G protein mutations have already been identified as well as those disorders for which the evidence is less definitive.