Development of a Method to Assess Biologically Relevant Dermal Exposure

This study has investigated the feasibility of developing a "biologically relevant" dermal sampler for toluene.

This prototype Institute of Occupational Medicine (IOM) dermal sampler consists of adsorbent sandwiched between a permeable membrane and an impervious backing.

Toluene on the membrane surface diffuses towards the adsorbent.

The concentration of toluene on the membrane surface may be estimated from this mass on the adsorbent and the known permeation rate of toluene through the membrane.